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6 16 17 Monitoring and evaluating health outcomes that are associated with the way medications are used in clinical practice is difficult, yet essential to understanding the ongoing safety and risk–benefit profiles of medications, and paramount to promoting their optimal use.Īdministrative databases, electronic health records and disease registries contain a plethora of health data that can be used to ascertain health outcomes in clinical practice. 16 Reasons include differences in patient populations, treatment indications (eg, off-label use), monitoring protocols, duration of drug exposure and compliance between the clinical practice setting and the controlled environment of clinical trials. 15Īdverse drug events that are encountered in clinical practice may vary substantially from those observed in pre-market clinical trials. 14 Efforts to optimize medication use and reduce adverse drug events are therefore a public health priority. 2–7 Adverse drug reactions alone, a subset of adverse drug events that occur when drugs are used in therapeutic doses, 8 cause 5–10% of acute care hospital admissions, 9–12 prolong hospital stays, 13 and may contribute to more potential years of life lost than all other injuries combined. Yet, a significant proportion will experience adverse drug events, the unintended and harmful effects resulting from medication use that are associated with suboptimal patient outcomes and increased health services utilization. 1 Patients who use indicated medications appropriately can expect to derive benefit. 1 In 2008, over 76% of Americans older than 60 years reported ingesting two or more prescribed medications daily, and 37% used five or more. I have IgA nephrology.The use of prescribed medications has risen dramatically in the past decades.Hypertensive crisis: What are the symptoms?.What is hypertension? A Mayo Clinic expert explains.

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Chronic kidney disease: Is a clinical trial right for me?.Can whole-grain foods lower blood pressure?.Calcium supplements: Do they interfere with blood pressure drugs?.Bump on the head: When is it a serious head injury?.Bone and joint problems associated with diabetes.Blood sugar levels can fluctuate for many reasons.Blood pressure tip: Know alcohol limits.Blood pressure readings: Why higher at home?.Blood pressure medications: Can they raise my triglycerides?.Blood pressure medication: Still necessary if I lose weight?.Blood pressure: Is it affected by cold weather?.Blood pressure: Does it have a daily pattern?.Blood pressure: Can it be higher in one arm?.Beta blockers: How do they affect exercise?.Beta blockers: Do they cause weight gain?.Artificial sweeteners: Any effect on blood sugar?.Anxiety: A cause of high blood pressure?.Angiotensin-converting enzyme (ACE) inhibitors.Alcohol: Does it affect blood pressure?.Major side effects and safety of calcium channel blockers. Philadelphia, Pa.: Elsevier Saunders 2018. In: Hypertension: A Companion to Braunwald's Heart Disease. In: Rutherford's Vascular Surgery and Endovascular Therapy. Atherosclerotic risk factors: Hypertension. Choice of drug therapy in primary (essential) hypertension.